Primary Immunodeficiency Disease & Recurrent Infections

Symptoms, Diagnosis, Treatment & Management

According to the leading experts in immunology, when part of the immune system is either absent or not functioning properly, it can result in an immune deficiency disease. When the cause of this deficiency is hereditary or genetic, it is called a primary immunodeficiency disease (PIDD). Researchers have identified more than 150* different kinds of PIDD.

The immune system is composed of white blood cells. These cells are made in the bone marrow and travel through the bloodstream and lymph nodes. They protect and defend against attacks by "foreign" invaders such as germs, bacteria and fungi.

Primary Immunodeficiency Disease Symptoms & Diagnosis

Serious PIDDs typically become apparent in infancy. In milder forms, it often takes a pattern of recurrent infections before PIDD is suspected. In some cases, a PIDD is not diagnosed until people reach their 20s and 30s.

Important signs that may indicate a PIDD include:

  • Recurrent, unusual or difficult to treat infections
  • Poor growth or loss of weight
  • Recurrent pneumonia, ear infections or sinusitis
  • Multiple courses of antibiotics or IV antibiotics necessary to clear infections
  • A family history of PIDD
  • Recurrent deep abscesses of the organs or skin
  • Swollen lymph glands or an enlarged spleen
  • Autoimmune disease

Some immunodeficiency disorders are not primary (hereditary or genetic). A secondary immune deficiency disease occurs when the immune system is compromised due to an environmental factor. Examples of these external causes include HIV, chemotherapy, severe burns or malnutrition.

Primary Immunodeficiency Disease Treatment & Management

Research in primary immunodefeciency is making great strides, improving treatment options and enhancing the quality of life for most people with these complex conditions.

How We Can Help

If you or your child has symptoms of these sometimes critical conditions, you want the best care available. Dr. Judge, An allergist and immunologist has specialized training and expertise to accurately diagnose and coordinate a treatment plan for PIDD